|
KMID : 1161520150190060417
|
|
Animal Cells and Systems
2015 Volume.19 No. 6 p.417 ~ p.424
|
|
|
SNPs in the 5' terminal-region of IGFBP6 gene and its linkage with pig body size
|
|
Fang Xibi
Liu Songcai
Cheng Yunyun
Li Siming
Wu Qingyan
Su Dan
Lu Chao
Yu Hao
Hao Linlin
|
|
|
Abstract
|
|
|
|
Insulin-like growth factor binding protein 6 (IGFBP6) is a key factor in regulating the effects of insulin-like growth factor 2 (IGF2) on the animal growth and development, but the mechanism is far from known. In this study, the 5'-terminal sequence of the IGFBP6 gene (from ?920 to ?1?bp) which may regulate gene expression was sequenced in the Bama mini-pigs, the Tibetan mini-pigs, the Landrace pigs, the Large White pigs and the Northeast wild boars to screen for the single nucleotide polymorphisms (SNPs) and analyze the relations with the body size traits of swine through a chi-square test analysis. The genotype frequencies of the SNPs in the 5'-terminal sequence have shown that c.-726C?>?T, c.-722T?>?C, c.-535C?>?A, c.-488T?>?C, c.-403A?>?G, and c.-378T?>?C may be related to the dwarf traits of the Bama mini-pig and the Tibetan mini-pigs (P?
|
|
|
KEYWORD
|
|
|
IGFBP6, SNPs, mini-pig, body size
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|